Mice in Bion-M 1 space mission: training and selection

Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells

Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System

Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae.

TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis.

Gravitropism and lateral root emergence are dependent on the trans-Golgi network protein TNO1

Toll mediated infection response is altered by gravity and spaceflight in Drosophila

FAIRness and usability for open-access omics data systems.

Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome

Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation

Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila

ERULUS is a plasma membrane-localized receptor-like kinase that specifies root hair growth by maintaining tip-focused cytoplasmic calcium oscillations.

Spatial and temporal localization of SPIRRIG and WAVE/SCAR reveal roles for these proteins in actin-mediated root hair development.

Manipulating the permeation of charged compounds through the MscL nanovalve.

The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface

Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade

Desiccation of Hypsibius exemplaris

Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading.

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation

Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1g on the Structure and Function of the Utricle in Toadfish, Opsanus tau.

Inter-regulation of the unfolded protein response and auxin signaling.

Unfolded protein response in plants: one master, many questions.

Reduced Chloroplast Coverage genes from Arabidopsis thaliana help to establish the size of the chloroplast compartment

Relevance of the Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis

Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana

Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target

Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments

Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections

Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight

Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station.

A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.

An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity

Spaceflight promotes biofilm formation by Pseudomonas aeruginosa.

Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact

NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data

NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions.

Fungal diversity differences in the indoor dust microbiome from built environments on Earth and in space.

Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation.

Exercise training augments regional bone and marrow blood flow during exercise.

Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice

Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.

Development of otolith receptors in Japanese quail.

Simulated Microgravity Enhances Oligodendrocyte Mitochondrial Function and Lipid Metabolism

Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space

Metabolomic profiling of the secretome from human neural stem cells flown into space.

The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit.

Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight.

Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana.

Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ

Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization

Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds

Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments

Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis.

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants.

A ROS-assisted calcium wave dependent on AtRBOHD and TPC1 propagates the systemic response to salt stress in Arabidopsis roots

Orchestrating rapid long-distance signaling in plants with Ca2+ , ROS, and electrical signals

Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana.

The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses.

Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue

Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight

Skeletal tissue regulation by catalase over-expression in mitochondria

Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila

Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model.

Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids

Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations

Endocrine Effects of Space Flight

Back pain in space and post-flight spine injury: Mechanisms and countermeasure development

Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.

Effects of mechanostimulation on gravitropism and signal persistence in flax roots.

Transcription profile of auxin related genes during positively gravitropic hypocotyl curvature of Brassica rapa.

Expression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytes

The ongoing search for the molecular basis of plant osmosensing

Effects of angular frequency during clinorotation on mesenchymal stem cell morphology and migration

To Infinity and Beyond! Human spaceflight and life science.

n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial

Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines.

Sierra Nevada sweep: Metagenomic measurements of bioaerosols vertically distributed across the troposphere.

Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight

Bone shaft bending strength index is unaffected by exercise and unloading in mice

Genetic and tissue level muscle-bone interactions during unloading and reambulation.

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.

A novel phototropic response to red light is revealed in microgravity.

Light and gravity signals synergize in modulating plant development

Comparison of Microgravity Analogs to Spaceflight in Studies of Plant Growth and Development

Red light enhances plant adaptation to spaceflight and Mars g-levels.

Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle.

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: Proof of concept.

Hardware validation of the Advanced Plant Habitat on ISS: Canopy photosynthesis in reduced gravity.

New insights into lignification via network and multi-omics analyses of arogenate dehydratase knock-out mutants in Arabidopsis thaliana

Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity.

Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.

A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.

Routine omics collection is a golden opportunity for European human research in space and analog environments.

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing

Spatiotemporal expression and control of haemoglobin in space

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.

Protective alleles and precision healthcare in crewed spaceflight

Microbiological and nutritional analysis of lettuce crops grown on the International Space Station

Gravity signaling in flowering plant roots

New device for high-throughput viability screening of flow biofilms

Microgravity alters the expression of salivary proteins

Effects of spaceflight on the mouse submandibular gland

The cyclic nucleotide-gated channel CNGC14 regulates root gravitropism in Arabidopsis thaliana.

Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states.

Transcriptional and Hormonal Regulation of Gravitropism of Woody Stems in Populus.

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.

Complete Genome Sequence of Carnobacterium gilichinskyi Strain WN1359T (DSM 27470T)

Cultivation of Staphylococcus epidermidis in the human spaceflight environment leads to alterations in the frequency and spectrum of spontaneous rifampicin-resistance mutations in the rpoB gene

Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment

Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.

Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance.

New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli

Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns.

Rapid phenotypic response of LSMMG-'primed' Candida albicans.

Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight.

Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics.

The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system.

Spaceflight transcriptomes: unique responses to a novel environment.

A method for preparing spaceflight RNAlater-fixed Arabidopsis thaliana (Brassicaceae) tissue for scanning electron microscopy.

HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.

Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.

Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression.

Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver

Transcriptomic effects on the mouse heart following 30 days on the International Space Station.

Phosphoinositide-signaling is one component of a robust plant defense response

RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques

Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research

The interaction of vortical flows with red cells in venous valve mimics.

Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis

Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants.

Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring.

Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation

ANN1 and ANN2 Function in Post-Phloem Sugar Transport in Root Tips to Affect Primary Root Growth

Longitudinal time course of muscle impairments during partial weight-bearing in rats

Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model

Effects of liquid cultivation on gene expression and phenotype of C. elegans.

Caenorhabditis elegans in microgravity: An omics perspective

Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease

Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days)

Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions

In situ linkage of fungal and bacterial proliferation to microbiologically influenced corrosion in B20 biodiesel storage tanks.

The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles

Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans.

Effects of sex and gender on adaptations to space: reproductive health

Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight.

Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice

Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.

Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice.

Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis

Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice

Leptin and environmental temperature as determinants of bone marrow adiposity in female mice

Simulated Microgravity Promotes Horizontal Gene Transfer of Antimicrobial Resistance Genes between Bacterial Genera in the Absence of Antibiotic Selective Pressure

Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media

Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration

A region of UNC-89 (obscurin) lying between two protein kinase domains is a highly elastic spring required for proper sarcomere organization

Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station.

Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans.

Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

Microbial existence in controlled habitats and their resistance to space conditions

Characterization of Aspergillus fumigatus isolates from air and surfaces of the International Space Station.

Human presence impacts fungal diversity of inflated lunar/Mars analog habitat.

Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station.

Draft genome sequence of a clinical isolate of Fusarium fujikuroi isolated from a male patient with acute myeloid leukemia.

Draft genome sequences of two Fusarium oxysporum isolates cultured from infected Zinnia hybrida plants grown on the International Space Station.

Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces

Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station

MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities

Draft Genome Sequences of Rhodotorula mucilaginosa Strains Isolated from the International Space Station

Draft Genome Sequences of Klebsiella Species Isolated from the International Space Station

Methylobacterium ajmalii sp. nov., isolated from the International Space Station

Effects of simulated microgravity on the proteome and secretome of the polyextremotolerant black fungus Knufia chersonesos.

Investigation of Spaceflight Induced Changes to Astronaut Microbiomes

Metabolic modeling of the International Space Station microbiome reveals key microbial interactions.

Characterization of metagenome-assembled genomes from the International Space Station.

Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018).

The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes

Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.

Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells

Mitigation and use of biofilms in space for the benefit of human space exploration

Draft genome sequence of Sphingomonas paucimobilis strain Sph5, isolated from tap water filtration membrane

CubeSats for microbiology and astrobiology research

Simulated micro-, lunar, and Martian gravities on Earth—effects on Escherichia coli growth, phenotype, and sensitivity to antibiotics.

Spatial Characterization of Microbial Communities on Multi-Species Leafy Greens Grown Simultaneously in the Vegetable Production Systems on the International Space Station

Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential.

Effects of Space Flight on Inflammasome Activation in the Brain of Mice.

Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats

Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication.

Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21

Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station

From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.

Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle

Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana.

TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana.

Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver

NASA GeneLab platform utilized for biological response to space radiation in animal models

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: Host extracellular to systemic effects of SARS-CoV-2 infection

Ethical considerations for the age of non-governmental space exploration

Regulation of plant gravity sensing and signaling by the actin cytoskeleton.

Brassinosteroids inhibit autotropic root straightening by modifying filamentous-actin organization and dynamics.

Microgravity Stress: Bone and Connective Tissue

The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.

The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves

Reply to Bemm et al. and Arakawa: Identifying foreign genes in independent Hypsibius dujardini genome assemblies

The biology of tardigrade disordered proteins in extreme stress tolerance.

Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass

Treatment with a soluble bone morphogenetic protein type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading.

Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth

Organization of the ER-Golgi interface for membrane traffic control.

Endoplasmic reticulum-shape and function in stress translation

Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes?

Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants.

Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement

Acceleration profiles and processing methods for parabolic flight.

Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment

Genomic and functional characterization of Enterococcus faecalis isolates recovered from the International Space Station and their potential for pathogenicity

Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster.

Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.

Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing

Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression

GeneLab: Omics database for spaceflight experiments

A New Era for Space Life Science: International Standards for Space Omics Processing

Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Celebrating 30 years of access to NASA space life sciences data

Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling.

Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.

Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery

Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium

Simulated microgravity induces regionally distinct neurovascular and structural remodeling of skeletal muscle and cutaneous arteries in the rat

Spatial and temporal characteristics of vestibular convergence

Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons

Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight

Strategies, research priorities, and challenges for the exploration of space beyond low-Earth orbit

Skewing in Arabidopsis roots involves disparate environmental signaling pathways.

Phenotypic characterization of an Arabidopsis T- DNA insertion line SALK_063500

Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana.

Articular cartilage and sternal fibrocartilage respond differently to extended microgravity.

Symbiotic organs shaped by distinct modes of genome evolution in cephalopods.

Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis

Microbiome metadata standards: Report of the National Microbiome Data Collaborative's workshop and follow-on activities.

Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station.

Calcium, mechanical signaling, and tip growth

Gravitropic signaling in plants

ROS, calcium and electric signals: Key mediators of rapid systemic signaling in plants

Glutamate triggers long-distance, calcium-based plant defense signaling.

The fast and the furious: Rapid long-range signaling in plants.

Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome

Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments

Influence of social isolation during prolonged simulated weightlessness by hindlimb unloading

Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells

Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations

Effects of space flight on mouse liver versus kidney: Gene pathway analyses.

Role of shear stress on renal proximal tubular cells for nephrotoxicity assays

Fifteen days of microgravity causes growth in calvaria of mice

Spaceflight-associated vascular remodeling and gene expression in mouse calvaria.

Oxygen dependency of germinating Brassica seeds.

High-gradient magnetic fields and starch metabolism: Results from a space experiment.

United in Diversity: Mechanosensitive Ion Channels in Plants

Plastid osmotic stress influences cell differentiation at the plant shoot apex.

The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization.

Hyperoxia inhibits T cell activation in mice

Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates

From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009.

Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment

Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response

Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces.

Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs.

Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains

Plant cell proliferation and growth are altered by microgravity conditions in spaceflight.

A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity.

The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiments

EUK-134 ameliorates nNOSµ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading.

Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise.

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station

Trimeric structure of (+)-pinoresinol-forming dirigent protein at 1.95 A resolution with three isolated active sites.

Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation

Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight

Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons

Evidence of spaceflight-induced adverse effects on photoreceptors and retinal function in the mouse eye.

Spatial omics technologies at multimodal and single cell/subcellular level.

Inspiration4 data access through the NASA Open Science Data Repository

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants

Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to cadaverine in Arabidopsis.

Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis

Sigma S-dependent antioxidant defense protects stationary-phase Escherichia coli against the bactericidal antibiotic gentamicin

Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions

Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation

Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections

Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis

Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.

Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response

Experimental Evolution of Bacillus subtilis

Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation

Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.

Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders.

Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells

Effects of Sex and Gender on Adaptation to Space: Immune System

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age.

Spaceflight enhances cell aggregation and random budding in Candida albicans.

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

Multiparameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans.

14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?

Fundamental plant biology enabled by the space shuttle.

ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight

Neutrophil to Lymphocyte ratio: A biomarker to monitor the immune status of astronauts.

Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis

Utilizing the KSC fixation tube to conduct human-tended plant biology experiments on a suborbital spaceflight

Changes in the distribution and function of leukocytes after whole-body iron ion irradiation.

Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

Spaceflight-induced gene expression profiles in the mouse brain are attenuated by treatment with the antioxidant BuOE

Uncovering transcriptional responses to fractional gravity in Arabidopsis roots

Functional changes in the snail statocyst system elicited by microgravity

Lab-on-a-chip approaches for space-biology research.

Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight

Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides

Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.

Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats.

Proteomic study of microsomal proteins reveals a key role for Arabidopsis Annexin 1 in mediating heat stress-induced increase in intracellular calcium levels.

Mitochondria-targeted human catalase in the mouse longevity MCAT model mitigates head-tilt bedrest-induced neuro-inflammation in the hippocampus.

The partial weight-bearing rat model using a pelvic harness does not impact stress or hindlimb blood flow.

Hindlimb suspension in Wistar rats: Sex-based differences in muscle response

Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments.

Dried plum diet protects from bone loss caused by ionizing radiation

Autophagy and its consequences for platelet biology

Morphology of Penicillium rubens Biofilms Formed in Space

Influence of the spaceflight environment on macrophage lineages

Identification of metagenome-assembled genomes containing antimicrobial resistance genes, isolated from an advanced water treatment facility.

Blocking SARS-CoV-2 Delta variant (B.1.617.2) spike protein receptor-binding domain binding with the ACE2 receptor of the host cell and inhibiting virus infections using human host defense peptide-conjugated graphene quantum dots.

Inhibition of Cytomegalovirus by Pentacta pygmaea Fucosylated Chondroitin Sulfate Depends on Its Molecular Weight

Effects of spaceflight on the muscles of the murine shoulder.

Failure to Generate Bone Marrow Adipocytes Does Not Protect Mice from Ovariectomy-Induced Osteopenia

Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss

Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation

Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.

Maintenance of near normal bone mass and architecture in lethally irradiated female mice following adoptive transfer with as few as 750 purified hematopoietic stem cells.

Effects of Spaceflight on Cancellous and Cortical Bone in Proximal Femur in Growing Rats

Small changes in thermoregulation influence cancellous bone turnover balance in distal femur metaphysis in growing female mice

Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions

Microfluidic Device for Studying Nematodes

Molecular muscle experiment: Hardware and operational lessons for future astrobiology space experiments

NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans

A Compact Imaging Platform for Conducting C. elegans Phenotypic Assays on Earth and in Spaceflight.

Spaceflight Induces Strength Decline in Caenorhabditis elegans

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Microbiomes of the dust particles collected from the International Space Station and Spacecraft assembly facilities

Draft genome sequences of biosafety level 2 opportunistic pathogens isolated from the environmental surfaces of the International Space Station.

Whole metagenome profiles of particulates collected from the International Space Station

Draft Genome Sequences of Acinetobacter and Bacillus Strains Isolated from Spacecraft-Associated Surfaces

Draft Genome Sequence of Solibacillus kalamii, Isolated from an Air Filter Aboard the International Space Station

Characterization of Aspergillus niger Isolated from the International Space Station

International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans.

Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces.

Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station

Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station

Draft Genome Sequences of Bacillaceae Strains Isolated from the International Space Station.

Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule

Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station

Genomic Characterization of Potential Plant Growth-Promoting Features of Sphingomonas Strains Isolated from the International Space Station

Microbial Burden Estimation of Food Items, Built Environments, and the International Space Station Using Film Media

Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station

Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis

Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation.

Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents

Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences.

Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana.

Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable water

Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism

In situ resource utilisation: The potential for space biomining

Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces.

Response of Arabidopsis thaliana and Mizuna mustard seeds to simulated space radiation exposures.

In situ monitoring of barrier function on-chip via automated, non-invasive luminescence sensing.

Immunization induces inflammation in the mouse heart during spaceflight.

NASA open science data repository: Open science for life in space.

Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station.

Stem Cell Health and Tissue Regeneration in Microgravity

Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart

High-precision method for cyclic loading of small-animal vertebrae to assess bone quality.

AtRabD2b and AtRabD2c have overlapping functions in pollen development and pollen tube growth.

Root growth movements: Waving and skewing.

The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus.

GeneLab database analyses suggest long-term impact of space radiation on the cardiovascular system by the activation of FYN through reactive oxygen species.

Circulating miRNA spaceflight signature reveals targets for countermeasure development

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.

Aging and putative frailty biomarkers are altered by spaceflight

Innate immune responses of Drosophila melanogaster are altered by spaceflight.

HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis

Cell type-specific imaging of calcium signaling in Arabidopsis thaliana seedling roots using GCaMP3.

S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins

Three routes to modulate the pore size of the MscL channel/nanovalve

Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity

Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation.

Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis

Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle

RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice

Morphology of the Utricular Otolith Organ in the Toadfish, Opsanus tau

IRE1: ER stress sensor and cell fate executor.

Galactose-depleted xycoglucan is dysfunctional and leads to dwarfism in Arabidopsis

Pectin methylesterification impacts the relationship between photosynthesis and plant growth.

NADPH oxidase activity is required for ER stress survival in plants.

High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments

Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.

Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties

Evaluation of in vitro macrophage differentiation during space flight.

Development and characterization of two porcine monocyte-derived macrophage cell lines.

Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line

Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice

Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability.

NASA GeneLab: Interfaces for the exploration of space omics data

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

Biological horizons: pioneering open science in the cosmos

Dichotomous effects on lymphatic transport with loss of caveolae in mice.

Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.

Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure

Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat.

Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

Bone remodeling is regulated by inner ear vestibular signals

Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight

Metabolomics profile of the secretome of space-flown oligodendrocytes.

Spaceflight Induces Specific Alterations in the Proteomes of Arabidopsis

Data for characterization of SALK_084889, a T-DNA insertion line of Arabidopsis thaliana

Utilization of single‚Äêimage normalized difference vegetation index (SI‚ÄêNDVI) for early plant stress detection

The Plant Health Monitoring System of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase